The Catalan giants have been underwhelming in La Liga, picking up just one point from a possible six on the road so far and conceding four goals in two home games.
It has been by no means a disastrous start and they still remain within three points of league leaders, Sevilla.
However, a defeat to Athletic Bilbao and a 2-2 draw with Osasuna does not inspire confidence in their away form and going to the Signal Iduna Park is never an easy task.
Dortmund have scored nine goals and conceded just one in two home Bundesliga games so far this season and possess a genuinely frightening amount of attacking options.
To be able to pick from a selection of Marco Reus, Jadon Sancho, Paco Alcacer, Julian Brandt and Thorgan Hazard is a headache any manager wants. Such a quick and exciting attack will cause plenty of problems for a Barcelona defence that has conceded almost two goals a game on average this season.
Selection: Dortmund to win @ 9/4
What a difference a year makes.
Last December, a slender win at home to Napoli was just about enough to prevent Liverpool being dumped out in the group stages – 10 10 months later, Liverpool head to Naples as European Champions.
Napoli will be gunning for revenge after that Anfield defeat last Christmas. Liverpool were very fortunate to come away with a 1-0 win, thanks in no small part to a splendid save from Alisson in the dying moments.
The Reds were also fortunate not to be reduced to 10 men after Virgil Van Dijk came close to snapping Dries Mertens’ leg in half, although Liverpool fans have become very touchy and insecure about the subject.
More recently, Liverpool have looked close to unstoppable in the fledgling days of their Premier League campaign and have built a five-point lead.
Napoli, meanwhile, have been on the right and wrong end of a 4-3 result and their defence seems worryingly porous, even though they have added Kostas Manolas to their ranks.
It all points to a high scoring game on Tuesday.
Selection: Both teams to score @8/15
Few would have seen Chelsea’s demolition of Wolves coming prior to Saturday. The Blues had been so average in their first four games that it seemed likely that Wolves would easily overturn them at Molineux.
What transpired was a Tammy Abraham masterclass and a massive Chelsea victory.
Frank Lampard now needs to ensure that it was not a flash in the pan, but a standard that Chelsea will reach all season.
They have so far drawn both of their league games at Stamford Bridge and will fancy their chances of setting that record straight against a Valencia side that have only picked up four points from four games in Spain.
This is the type of game that Lampard needs to win if he is to have a successful debut campaign in the Chelsea hot-seat.
Selection: Chelsea to win @ 4/5